{"product_id":"lifeblud-energi","title":"LifeBlud Energi+ B Complex","description":"\u003ch4\u003e\n\u003cstrong data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e\u003cstrong\u003eUse \"Sher\" at checkout for 10% off any of LifeBlud's products!\u003c\/strong\u003e\n\u003c\/h4\u003e\n\u003cp\u003eThe Best B Complex on Earth.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eServing size: 2 capsules. 120 capsules per bottle.\u003cbr\u003eEach capsule contains:\u003cbr\u003e\u003c\/strong\u003e\u003cbr\u003eB1: Benfotiamine : 50mg\u003cbr data-mce-fragment=\"1\"\u003eB2: Riboflavin 5-Phosphate: 25mg\u003cbr data-mce-fragment=\"1\"\u003eB3: Niacinamide : 125mg\u003cbr data-mce-fragment=\"1\"\u003eB5: Calcium D-Pantothenate: 10mg\u003cbr data-mce-fragment=\"1\"\u003eB6: Pyridoxal 5-Phosphate: 5mg\u003cbr data-mce-fragment=\"1\"\u003eB9: L-5-MTHF: 500mcg\u003cbr data-mce-fragment=\"1\"\u003eB12: Adenosylcobalamin: 500mcg\u003cbr\u003eBiotin: 25mcg\u003cbr data-mce-fragment=\"1\"\u003eInositol: 25mg\u003cbr\u003e\u003cbr\u003eNon-medicinal ingredients: gelatin, rice hull powder, magnesium stearate.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003e3RD PARTY LAB TESTED FOR PURITY. \u003c\/strong\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cbr\u003e\u003cbr\u003e\u003c\/span\u003e\u003cstrong\u003eWhat makes Energi+ unique? \u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003ePut simply, Energi+ was formulated with the \u003cstrong\u003ebest\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eand \u003cstrong\u003emost bioactive\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eforms of the B Vitamins, in amounts that coincide with the bioenergetic perspective of optimizing cellular energy production. No corners were cut with Energi+. \u003cbr\u003e\u003cbr\u003eIn specific - the following are the major upgrades you get with Energi+, as opposed to other B complex products out there.\u003cbr\u003e\u003cbr\u003e1. Thiamine HCl --\u0026gt;\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eBenfotiamine \u003c\/strong\u003e\u003cbr\u003e2. Niacin --\u0026gt;\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eNiacinamide\u003c\/strong\u003e\u003cbr\u003e3. Folic Acid --\u0026gt;\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eL-5-Methyl Folate\u003c\/strong\u003e\u003cbr\u003e4. Methylcobalamin --\u0026gt;\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eAdenosylcobalamin\u003cbr\u003e\u003c\/strong\u003e5. Cellulose capsule --\u0026gt;\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eBovine gelatin capsule\u003cbr\u003e\u003c\/strong\u003e6. No silicon dioxide, no filler!\u003cbr\u003e\u003cstrong\u003e\u003cbr\u003e\u003cbr\u003ePRODUCT SPOTLIGHTS:\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eBenfotiamine\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003eBenfotiamine is a fat-soluble form of Vitamin B1 Thiamine. Benfotiamine has been extensively studied to have a\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003emuch higher bioavailable\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ecapacity than the standard Thiamine HCl. Since it is fat soluble, and not water soluble, it is able to stay in the system for a longer period of time without being excreted. Research suggests it is 3-4x as effective [2,3]. \u003cbr\u003e\u003cbr\u003eBenfotiamine not only delivers a more bioactive array of benefits from Vitamin B1 around i\u003cstrong\u003emproving glucose utilization\u003c\/strong\u003e,\u003cstrong\u003e\u003cspan\u003e \u003c\/span\u003epyruvate dehydrogenase activation\u003c\/strong\u003e, anti-tumor and anti-cancer effects, and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eneuroprotection\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e[4-7], but also has added benefits of antioxidant and anti-inflammatory effect. It has been shown to reduce DNA damage [8], and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003emediate the inflammatory response caused by endotoxin (LPS) and PUFA\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e[9]. \u003cbr\u003e\u003cbr\u003eAlcohol and Vitamin B1 have an inverse relationship, and there is evidence to suggest that\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eB1 deficiency caused by alcohol\u003c\/strong\u003e, can cause iron-mediated brain damage [12]. B1 seems to be a very crucial component when it comes to\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003erecovering from alcohol\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003euse. Benfotiamine has also been shown to have a\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eliver protective\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eeffect [11]. \u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eNiacinamide\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003eNiacinamide does not need much of an introduction at this point. However, it is important to note that Niacinamide is much preferred over Niacin!\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eNiacin\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ecommonly induces a '\u003cstrong\u003eflushing'\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ereaction, which is just a nice way of saying\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003einflammatory response\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e[14]. \u003cbr\u003e\u003cbr\u003eNot only does\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eNiacinamide\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003enot induce this inflammatory response, but it greatly increases our ability to\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eutilize carbohydrates as energy\u003c\/strong\u003e,\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003elowers free fatty acids\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ein the blood, and increases cellular\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eNAD+\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003elevels. These processes make it an incredible tool, especially for someone who needs help switching to a diet with emphasis on\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eburning carbohydrate\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eefficiently as fuel. \u003cbr\u003e\u003cbr\u003eImportant to note though, is that i\u003cstrong\u003encreased Niacinamide intake\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ealso requires an increased\u003cstrong\u003e\u003cspan\u003e \u003c\/span\u003edemand\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003efor the\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003emethyl donors\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e[15]\u003cstrong\u003e.  \u003c\/strong\u003eNiacinamide must be methylated and therefore can use up high amounts of methyl donors. These donors are choline, methionine,\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eB9 Folate\u003c\/strong\u003e, and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eB12\u003c\/strong\u003e. This is why Energi+ contains the most biologically active forms of both B9 and B12.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eL5-Methyl Folate (MTHF)\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003eL-5-MTHF is the\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003emost biologically active form of folate\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eand is found in nature and in whole foods. \u003cbr\u003e\u003cbr\u003eMost supplemental folates are in the form of Folic Acid. The body has to\u003cstrong\u003e\u003cspan\u003e \u003c\/span\u003econvert folic acid into Methylfolate\u003c\/strong\u003e, and many people struggle with that process due to stress, current biological situation, genetics, and so forth. Unmetabolized folic acid in the body can cause problems [16-17]. \u003cbr\u003e\u003cbr\u003eL-5-MTHF can support\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003emethylation\u003c\/strong\u003e, in tandem with B12, which will not only\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003emaximize the efficiency\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eof supplemental Niacinamide, but also helps many other processes such as\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eDNA synthesis, hormone conversion\u003c\/strong\u003e, and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003ehomocysteine regulation\u003c\/strong\u003e. \u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eAdenosylcobalamin\u003cbr\u003e\u003cbr\u003e\u003c\/strong\u003eAdenosylcobalamin is the form of B12 that is\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eused directly in the mitochondria\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003eto create energy, in the Citric Acid Cycle. \u003cbr\u003e\u003cbr\u003eMost B complexes out there contain Methylcobalamin. Similar to L-5-MTHF, the body\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003emust convert\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003emethylcobalamin into adenosylcobalamin so that it can be used to\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003ecreate energy in the cell\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003e[18-19]. \u003cbr\u003e\u003cbr\u003eThis makes\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eAdenosylcobalamin the best choice\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ewhen it comes to taking a B12 supplement that is going to be\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eeasily absorbed\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eby the body, and\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eassist in the energy production process\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eas best possible. \u003cstrong\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003eB Vitamin Cheat Sheet: \u003cbr\u003e\u003cbr\u003eB1 Thiamine:\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e- Plays a critical role in the metabolism of carbohydrates into energy\u003cstrong\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e- Cofactor for the enzyme Pyruvate Dehydrogenase (PDH)\u003cbr data-mce-fragment=\"1\"\u003e- PDH is one of the main enzymes that converts glucose from carbohydrate into energy\u003cbr data-mce-fragment=\"1\"\u003e- Used in synthesis of the neurotransmitter acetylcholine (ACH)\u003cbr data-mce-fragment=\"1\"\u003e- Improve glucose use\u003cstrong\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eB2 Riboflavin\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e- Required for FAD and FMN which are mitochondrial energy production enzymes\u003cbr data-mce-fragment=\"1\"\u003e- Assists in carbohydrate, fat, and protein metabolism\u003cbr data-mce-fragment=\"1\"\u003e- Facilitates the normalization of MTHFR enzyme activity\u003cbr data-mce-fragment=\"1\"\u003e- Assists glutathione recycling\u003cbr\u003e\u003cstrong\u003e\u003cbr data-mce-fragment=\"1\"\u003eB3 Niacinamide\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e- Stimulates mitochondrial energy production\u003cbr data-mce-fragment=\"1\"\u003e- Lowers free fatty acids in the blood\u003cbr data-mce-fragment=\"1\"\u003e- Assists greatly with carbohydrate metabolism\u003cbr data-mce-fragment=\"1\"\u003e- Increase NAD+\u003cbr data-mce-fragment=\"1\"\u003e- May lower cholesterol\u003cbr data-mce-fragment=\"1\"\u003e- Neuroprotection\u003cstrong\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eB5 Pantothenic Acid\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e- Energy metabolism\u003cbr data-mce-fragment=\"1\"\u003e- Synthesis of coenzyme A (Acetyl-CoA - mitochondrial energy molecule!)\u003cbr data-mce-fragment=\"1\"\u003e- Supports myelin production \u0026amp; neurotransmitter Acetylcholine\u003cstrong\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eB6 Pyridoxine\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e- Helps recycle cysteine into glutathione\u003cbr data-mce-fragment=\"1\"\u003e- Required in monoamine synthesis (dopamine, GABA, serotonin, epinephrines)\u003cbr data-mce-fragment=\"1\"\u003e- Energy metabolism\u003cbr data-mce-fragment=\"1\"\u003e- Aids liver detoxification\u003cstrong\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eB7 Biotin:\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e- Involved in hair, skin, and nail health\u003cbr data-mce-fragment=\"1\"\u003e- Coenzyme in carboxylation reactions\u003cbr data-mce-fragment=\"1\"\u003e- Aids insulin production\u003cbr data-mce-fragment=\"1\"\u003e- Aids aerobic oxidative metabolism\u003cstrong\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eB9 Folate\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e- DNA synthesis \u0026amp; repair\u003cbr data-mce-fragment=\"1\"\u003e- Methylation\u003cbr data-mce-fragment=\"1\"\u003e- Amino acid metabolism \u0026amp; conversion\u003cbr data-mce-fragment=\"1\"\u003e- Homocysteine regulation\u003cbr data-mce-fragment=\"1\"\u003e- Blood cell production\u003cbr data-mce-fragment=\"1\"\u003e- Required in rapid cell division \u0026amp; growth\u003cbr data-mce-fragment=\"1\"\u003e- Can help prevent neural tube defects\u003cbr data-mce-fragment=\"1\"\u003e- Methylfolate prevents glycine wasting\u003cstrong\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eB12 Cobalamin\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e- New red blood cell production\u003cbr data-mce-fragment=\"1\"\u003e- Used alongside B9 in homocysteine regulation\u003cbr data-mce-fragment=\"1\"\u003e- DNA synthesis \u0026amp; repair\u003cbr data-mce-fragment=\"1\"\u003e- Aids in energy metabolism\u003cbr data-mce-fragment=\"1\"\u003e- Helps maintain nerve sheaths\u003cstrong\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eInositol\u003c\/strong\u003e\u003cbr\u003e- Improves insulin sensitivity\u003cbr\u003e- Aids liver function \u003cbr\u003e- Hormone balance\u003cbr\u003e- Mood improvement\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003e1.\u003cstrong\u003e \u003c\/strong\u003e\u003cspan data-mce-fragment=\"1\"\u003eInstitute of Medicine. 1998.\u003cstrong\u003e \u003c\/strong\u003e\u003c\/span\u003e\u003cstrong\u003e\u003cem data-mce-fragment=\"1\"\u003eDietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline\u003c\/em\u003e\u003c\/strong\u003e. Washington, DC: The National Academies Press. https:\/\/doi.org\/10.17226\/6015.\u003cbr\u003e\u003ca href=\"https:\/\/www.nap.edu\/read\/6015\/chapter\/1\" data-mce-href=\"https:\/\/www.nap.edu\/read\/6015\/chapter\/1\"\u003ehttps:\/\/www.nap.edu\/read\/6015\/chapter\/1\u003cbr\u003e\u003c\/a\u003e\u003cbr\u003e2. Xie F, Cheng Z, Li S, Liu X, Guo X, Yu P, Gu Z.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003ePharmacokinetic study of benfotiamine and the bioavailability assessment compared to thiamine hydrochloride\u003c\/strong\u003e\u003c\/em\u003e. J Clin Pharmacol. 2014 Jun;54(6):688-95. doi: 10.1002\/jcph.261. Epub 2014 Jan 22. PMID: 24399744.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24399744\/\" data-mce-href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24399744\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/24399744\/\u003cbr\u003e\u003cbr\u003e\u003c\/a\u003e3. Loew D.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003ePharmacokinetics of thiamine derivatives especially of benfotiamine\u003c\/strong\u003e\u003c\/em\u003e. Int J Clin Pharmacol Ther. 1996 Feb;34(2):47-50. PMID: 8929745.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8929745\/\" data-mce-href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8929745\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/8929745\/\u003c\/a\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e4. Lee BY, Yanamandra K, Bocchini JA Jr.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eThiamin deficiency: a possible major cause of some tumors?\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003e(review). Oncol Rep. 2005 Dec;14(6):1589-92. PMID: 16273261.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16273261\/\" data-mce-href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16273261\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/16273261\/\u003cbr\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e5. \u003cspan data-mce-fragment=\"1\"\u003eVelichko MG, Ostrovskiĭ IuM, Trebukhina RV. Tiamin i obmen piruvata u krys-opukholenositeleĭ \u003cem\u003e\u003cstrong\u003e[Thiamine and pyruvate metabolism in tumor-bearing rats]\u003c\/strong\u003e\u003c\/em\u003e. Vopr Med Khim. 1978 Mar-Apr;24(2):220-4. Russian. PMID: 664448.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/664448\/\" data-mce-href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/664448\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/664448\/\u003cbr\u003e\u003cbr\u003e\u003c\/a\u003e6. \u003c\/span\u003eSambon M, Wins P, Bettendorff L.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eNeuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine.\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eInt J Mol Sci. 2021 May 21;22(11):5418. doi: 10.3390\/ijms22115418. PMID: 34063830; PMCID: PMC8196556.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34063830\/\" data-mce-href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34063830\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/34063830\/\u003cbr\u003e\u003cbr\u003e\u003c\/a\u003e7. \u003cspan data-mce-fragment=\"1\"\u003eHanberry, B.S., Berger, R. \u0026amp; Zastre, J.A. \u003cem\u003e\u003cstrong\u003eHigh-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate.\u003c\/strong\u003e\u003c\/em\u003e \u003c\/span\u003e\u003ci data-mce-fragment=\"1\"\u003eCancer Chemother Pharmacol\u003c\/i\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003cb data-mce-fragment=\"1\"\u003e73,\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003c\/b\u003e\u003cspan data-mce-fragment=\"1\"\u003e585–594 (2014). https:\/\/doi.org\/10.1007\/s00280-014-2386-z\u003cbr\u003e\u003cbr\u003e8. \u003c\/span\u003eSchmid U, Stopper H, Heidland A, Schupp N.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eBenfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro\u003c\/strong\u003e\u003c\/em\u003e. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7. doi: 10.1002\/dmrr.860. PMID: 18384109.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18384109\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/18384109\/\u003cbr\u003e\u003cbr\u003e\u003c\/a\u003e9. \u003cspan data-mce-fragment=\"1\"\u003eShoeb M, Ramana KV. \u003cem\u003e\u003cstrong\u003eAnti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages.\u003c\/strong\u003e\u003c\/em\u003e \u003c\/span\u003e\u003ci data-mce-fragment=\"1\"\u003eFree Radic Biol Med\u003c\/i\u003e\u003cspan data-mce-fragment=\"1\"\u003e. 2012;52(1):182-190. doi:10.1016\/j.freeradbiomed.2011.10.444\u003c\/span\u003e\u003cbr\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3249497\/\"\u003ehttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3249497\/\u003cbr\u003e\u003cbr\u003e\u003c\/a\u003e10. \u003cspan data-mce-fragment=\"1\"\u003eFraser, D.A., Hessvik, N.P., Nikolić, N. \u003c\/span\u003e\u003ci data-mce-fragment=\"1\"\u003eet al.\u003c\/i\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003cem\u003e\u003cstrong\u003eBenfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations.\u003c\/strong\u003e\u003c\/em\u003e \u003c\/span\u003e\u003ci data-mce-fragment=\"1\"\u003eGenes Nutr\u003c\/i\u003e\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003cb data-mce-fragment=\"1\"\u003e7,\u003cspan data-mce-fragment=\"1\"\u003e \u003c\/span\u003e\u003c\/b\u003e\u003cspan data-mce-fragment=\"1\"\u003e459–469 (2012). https:\/\/doi.org\/10.1007\/s12263-011-0252-8\u003cbr\u003e\u003ca href=\"https:\/\/genesandnutrition.biomedcentral.com\/articles\/10.1007\/s12263-011-0252-8#citeas\"\u003ehttps:\/\/genesandnutrition.biomedcentral.com\/articles\/10.1007\/s12263-011-0252-8\u003c\/a\u003e\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e11. Aziz, T. \u003cem\u003e\u003cstrong\u003eEffect of benfotiamine on hepatic tissue levels of free calcium, copper, iron and zinc during CCl4-induced hepatotoxicity in rats. \u003c\/strong\u003e\u003c\/em\u003eZanco J. Med. Sci., Vol. 15, No. (2), 2011.\u003cbr\u003e\u003ca href=\"https:\/\/www.researchgate.net\/publication\/324454848_Effect_of_benfotiamine_on_hepatic_tissue_levels_of_Effect_of_benfotiamine_on_hepatic_tissue_levels_of_free_calcium_copper_iron_and_zinc_during_CCl4-induced_hepatotoxicity_in_rats\" data-mce-href=\"https:\/\/www.researchgate.net\/publication\/324454848_Effect_of_benfotiamine_on_hepatic_tissue_levels_of_Effect_of_benfotiamine_on_hepatic_tissue_levels_of_free_calcium_copper_iron_and_zinc_during_CCl4-induced_hepatotoxicity_in_rats\"\u003ehttps:\/\/www.researchgate.net\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e12. \u003cspan data-mce-fragment=\"1\"\u003eMedical University of Vienna. \u003cem\u003e\u003cstrong\u003e\"Vitamin B1 deficiency a key factor in the development of alcohol-related dementia: Hypothesis describes the role of iron deposits in the brain as the cause of dementia in alcoholics.\"\u003c\/strong\u003e\u003c\/em\u003e ScienceDaily. ScienceDaily, 9 September 2020. \u003cbr\u003e\u003ca href=\"https:\/\/www.sciencedaily.com\/releases\/2020\/09\/200909100248.htm\" data-mce-href=\"https:\/\/www.sciencedaily.com\/releases\/2020\/09\/200909100248.htm\"\u003ehttps:\/\/www.sciencedaily.com\/releases\/2020\/09\/200909100248.htm\u003cbr\u003e\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e13. Balakumar P, Rohilla A, Krishan P, Solairaj P, Thangathirupathi A.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eThe multifaceted therapeutic potential of benfotiamine.\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003ePharmacol Res. 2010 Jun;61(6):482-8. doi: 10.1016\/j.phrs.2010.02.008. Epub 2010 Feb 25. PMID: 20188835.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20188835\/\" data-mce-href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20188835\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/20188835\/\u003c\/a\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e14. Kamanna VS, Ganji SH, Kashyap ML.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eThe mechanism and mitigation of niacin-induced flushing.\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eInt J Clin Pract. 2009 Sep;63(9):1369-77. doi: 10.1111\/j.1742-1241.2009.02099.x. PMID: 19691622; PMCID: PMC2779993.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19691622\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/19691622\/\u003c\/a\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e15. Sun WP, Li D, Lun YZ, Gong XJ, Sun SX, Guo M, Jing LX, Zhang LB, Xiao FC, Zhou SS.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eExcess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives.\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e\u003c\/em\u003eHypertens Res. 2012 Feb;35(2):180-5. doi: 10.1038\/hr.2011.151. Epub 2011 Sep 15. PMID: 21918528.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21918528\/\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/21918528\/\u003cbr\u003e\u003c\/span\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003e16. \u003c\/span\u003eHenderson AM, Aleliunas RE, Loh SP, Khor GL, Harvey-Leeson S, Glier MB, Kitts DD, Green TJ, Devlin AM.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003el-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women.\u003c\/strong\u003e\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003eJ Nutr. 2018 Jun 1;148(6):885-890. doi: 10.1093\/jn\/nxy057. PMID: 29878267.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29878267\/\" data-mce-href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29878267\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/29878267\/\u003cbr\u003e\u003cbr\u003e\u003c\/a\u003e17. Seremak-Mrozikiewicz A. Metafolina--alternatywa dla suplementacji niedoboru folianów u kobiet ciezarnych [\u003cem\u003e\u003cstrong\u003eMetafolin--alternative for folate deficiency supplementation in pregnant women\u003c\/strong\u003e\u003c\/em\u003e]. Ginekol Pol. 2013 Jul;84(7):641-6. Polish. doi: 10.17772\/gp\/1618. PMID: 24032278.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\" data-mce-href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/24032278\/\u003cbr\u003e\u003cbr\u003e\u003c\/a\u003e18. Thakkar K, Billa G.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eTreatment of vitamin B12 deficiency-methylcobalamine? Cyancobalamine? Hydroxocobalamin?-clearing the confusion\u003c\/strong\u003e\u003c\/em\u003e. Eur J Clin Nutr. 2015 Jan;69(1):1-2. doi: 10.1038\/ejcn.2014.165. Epub 2014 Aug 13. PMID: 25117994.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25117994\/\" data-mce-href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25117994\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/25117994\/\u003cbr\u003e\u003cbr\u003e\u003c\/a\u003e19. Marsh EN, Meléndez GD.\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eAdenosylcobalamin enzymes: theory and experiment begin to converge\u003c\/strong\u003e\u003c\/em\u003e. Biochim Biophys Acta. 2012 Nov;1824(11):1154-64. doi: 10.1016\/j.bbapap.2012.03.012. Epub 2012 Apr 3. PMID: 22516318; PMCID: PMC3580769.\u003cbr\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22516318\/\"\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/22516318\/\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5 class=\"sow-accordion-panel-border\"\u003e\u003cstrong\u003eMy Thoughts: This is a great complex I and my family take everyday. Even if you eat a variety of food groups with more than enough to eat, you likely still do not get enough B vitamins. This blend helps keep up on top of them. I like it best combined with bee pollen, which is one of the other best sources of B vitamins. Great for a cognition and natural energy boost! \u003c\/strong\u003e\u003c\/h5\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"LifeBlud","offers":[{"title":"Default Title","offer_id":42472592179360,"sku":"","price":32.4,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0603\/2182\/4928\/products\/Energi_Front_1600x_jpg.webp?v=1661232451","url":"https:\/\/www.sherangad.co\/products\/lifeblud-energi","provider":"Sher Angad","version":"1.0","type":"link"}